SNARE complex: A drug target and biomarker (P17813)

Target Name: SNARE complex

NCBI ID: P17813

SNARE complex

Other Name(s): None

SNARE complex: A drug target and biomarker

The SNARE complex is a protein family that plays a crucial role in the regulation of cell-cell interactions and cytoskeletal organization. It is composed of five subunits: Sn3, Sn2, Sn1, P1, and P2. The SNARE complex is involved in various cellular processes, including cell adhesion, migration, and intracellular signaling. It is also implicated in diseases such as cancer, neurodegenerative diseases, and autoimmune disorders. As a result, the SNARE complex has become an attractive drug target and a potential biomarker for a variety of diseases.

The SNARE complex functions as a protein-protein interaction (PPI) complex. It consists of five subunits that form a 尾-sheet structure. The 尾-sheet is the protein-protein interface where the subunits interact with each other. The SNARE complex has a unique 尾-sheet structure that is composed of two parallel 尾-strands and three parallel 尾-helices. This structure allows for the formation of a large interface that can accommodate various ligands and interactors.

The SNARE complex is involved in many cellular processes, including cell adhesion, migration, and intracellular signaling. One of the well-known functions of the SNARE complex is its role in cell adhesion. The complex helps to regulate the formation and maintenance of tight junctions , which are a type of cell-cell adhesion that is critical for maintaining tissue structure and function.

The SNARE complex is also involved in intracellular signaling. It can interact with various signaling molecules, including TGF-β, NF-kappa-B, and MAPKs. These interactions can regulate various cellular processes, including cell growth, differentiation, and inflammation.

The SNARE complex is implicated in many diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, the SNARE complex has been implicated in the development and progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. It is also involved in the regulation of cancer cell growth and metastasis.

As a result of its involvement in these diseases, the SNARE complex has become an attractive drug target. Several drugs that have been developed specifically to target the SNARE complex have been shown to be effective in preclinical studies. These drugs include small molecules, peptides, and proteins that can interact with the SNARE complex and modulate its function.

One of the most promising drugs that targets the SNARE complex is a small molecule called WQ101. WQ101 is a compounds that can inhibit the interaction between the SNARE complex and its ligands. Preclinical studies have shown that WQ101 can reverse the effects of neurodegenerative diseases, such as memory loss and motor neuron dysfunction, in animal models.

Another promising drug that targets the SNARE complex is a protein called ANO63. ANO63 is a small protein that can interact with the SNARE complex and regulate its function. Preclinical studies have shown that ANO63 can inhibit the migration and invasion of cancer cells, making it a potential drug for cancer treatment.

In addition to these drugs, the SNARE complex is also a potential biomarker for many diseases. The complex can be used as a protein biomarker for diseases such as neurodegenerative diseases, cancer, and autoimmune disorders. Its involvement in these diseases makes it an attractive target for diagnostic tests and therapeutic interventions.

Overall, the SNARE complex is a protein family that plays a crucial role in the regulation of cell-cell interactions and cytoskeletal organization. Its unique 尾-sheet structure and involvement in various cellular processes make it an attractive drug target and a potential biomarker for many diseases. The development of drugs that specifically target the SNARE complex has the potential to revolutionize our understanding of these diseases and improve treatment outcomes.

Protein Name: SNARE Complex

The "SNARE complex Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SNARE complex comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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